MabThera/MabThera SC Caution For Usage

Instructions for Use, Handling and Disposal: Mabthera: Withdraw the required amount of MabThera/Rituxan under aseptic conditions and dilute to a calculated rituximab concentration of 1 - 4 mg/mL in an infusion bag containing sterile, non-pyrogenic 0.9%, aqueous saline solution or 5% aqueous dextrose solution. To mix the solution, gently invert the bag to avoid foaming. Care must be taken to ensure the sterility of prepared solutions. Since the medicinal product does not contain any anti-microbial preservative or bacteriostatic agents, aseptic technique must be observed. Parenteral medications should be inspected visually for particulate matter or discoloration prior to administration.
The prepared infusion solution of MabThera/Rituxan IV is physically and chemically stable for 24 hours at 2°C - 8°C and subsequently 12 hours at room temperature.
MabThera SC: MabThera/Rituxan SC solution (once transferred from the vial into the syringe) is physically and chemically stable for 48 hours at 2°C - 8°C and subsequent 8 hours at 30°C in diffused daylight.
MabThera/Rituxan SC is provided in sterile, preservative-free, non-pyrogenic, single use vials.
Incompatibilities: MabThera: No incompatibilities between MabThera/Rituxan IV and polyvinyl chloride or polyethylene bags or infusion sets have been observed.
MabThera SC: No incompatibilities between MabThera/Rituxan SC and polypropylene or polycarbonate syringe material or stainless steel transfer and injection needles have been observed.
Disposal of unused/expired medicines: MabThera/MabThera SC: The release of pharmaceuticals in the environment should be minimized. Medicines should not be disposed of via wastewater and disposal through household waste should be avoided. Use established "collection systems", if available in the location.
The following points should be strictly adhered to regarding the use and disposal of syringes and other medicinal sharps: Needles and syringes should never be reused.
Place all used needles and syringes into a sharps container (puncture-proof disposable container).
Any unused medicinal product or waste material should be disposed of in accordance with local requirements.